The findings, published in The Lancet Psychiatry, analyse seventy six randomised trials and offer clear guidance on how patients can safely stop treatment.
According to the review, the combination of slow tapering and structured psychological support is the most successful method for preventing the return of depressive symptoms in the first year after discontinuation. Researchers noted that this approach can reduce the risk of relapse in about one in five patients, a benefit comparable to stopping suddenly but with far greater safety and stability.
The analysis pointed to two decisive factors. The first is a gradual taper lasting longer than four weeks. The second is receiving psychological support during the tapering process, including cognitive behavioural therapy and mindfulness based programmes.
Co author Debora Zaccoletti of the University of Verona said that psychological support offers a safe and effective option, even for short term treatment. The study found that slow tapering combined with psychological therapy lowered relapse risk by forty eight percent.
Experts emphasised that while this strategy works for many, antidepressants remain essential for treating acute episodes of depression. The review also acknowledged certain limitations due to insufficient evidence on long term psychotherapy outcomes.
Lead author Giovanni Ostuzzi said that for most patients discontinuing antidepressants is achievable, but it should always be discussed with a specialist and planned according to personal needs. He added that the findings could reshape global approaches to managing the process of stopping antidepressant use.
Data from the NHS Business Services Authority shows that nearly nine million people in England used antidepressants last year. Zaccoletti said the results highlight the need to update clinical guidelines so that patients receive individualised plans for gradual tapering supported by regular reviews and structured psychological care.
